| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50241440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1669855 (CHEMBL4019743) |
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| IC50 | 93±n/a nM |
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| Citation |  Dong, G; Chen, W; Wang, X; Yang, X; Xu, T; Wang, P; Zhang, W; Rao, Y; Miao, C; Sheng, C Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem60:7965-7983 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50241440 |
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| n/a |
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| Name | BDBM50241440 |
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| Synonyms: | CHEMBL4070033 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N5O2 |
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| Mol. Mass. | 385.4186 |
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| SMILES | Nc1ccccc1NC(=O)c1ccc(CNC(=O)c2ccc3cncn3c2)cc1 |
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| Structure | 
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