| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Mdm4 |
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| Ligand | BDBM50241628 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670059 (CHEMBL4019947) |
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| IC50 | 215±n/a nM |
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| Citation |  Giustiniano, M; Daniele, S; Pelliccia, S; La Pietra, V; Pietrobono, D; Brancaccio, D; Cosconati, S; Messere, A; Giuntini, S; Cerofolini, L; Fragai, M; Luchinat, C; Taliani, S; La Regina, G; Da Settimo, F; Silvestri, R; Martini, C; Novellino, E; Marinelli, L Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. J Med Chem60:8115-8130 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Mdm4 |
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| Name: | Protein Mdm4 |
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| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 54842.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
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| Residue: | 490 |
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| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
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| BDBM50241628 |
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| n/a |
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| Name | BDBM50241628 |
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| Synonyms: | CHEMBL4084848 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23NO4 |
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| Mol. Mass. | 389.4437 |
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| SMILES | OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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