| Reaction Details |
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 | Report a problem with these data |
| Target | Polycomb protein EED |
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| Ligand | BDBM223985 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670155 (CHEMBL4020043) |
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| Kd | 6.0±n/a nM |
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| Citation |  Wang, Y; Edalji, RP; Panchal, SC; Sun, C; Djuric, SW; Vasudevan, A Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program. J Med Chem60:8321-8335 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polycomb protein EED |
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| Name: | Polycomb protein EED |
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| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
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| Type: | Protein |
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| Mol. Mass.: | 50201.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75530 |
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| Residue: | 441 |
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| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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| BDBM223985 |
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| n/a |
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| Name | BDBM223985 |
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| Synonyms: | rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (2) |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28FN3 |
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| Mol. Mass. | 365.4869 |
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| SMILES | CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1cn(C)c2ccccc12 |r| |
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| Structure | 
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