Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetE3 ubiquitin-protein ligase TRIM33
LigandBDBM220447
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1670390 (CHEMBL4020278)
Kd>1000±n/a nM
Citation McDaniel, KFWang, LSoltwedel, TFidanze, SDHasvold, LALiu, DMantei, RAPratt, JKSheppard, GSBui, MHFaivre, EJHuang, XLi, LLin, XWang, RWarder, SEWilcox, DAlbert, DHMagoc, TJRajaraman, GPark, CHHutchins, CWShen, JJEdalji, RPSun, CCMartin, RGao, WWong, SFang, GElmore, SWShen, YKati, WM Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor. J Med Chem60:8369-8384 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase TRIM33
Name:E3 ubiquitin-protein ligase TRIM33
Synonyms:6.3.2.- | E3 ubiquitin-protein ligase TRIM33 | Ectodermin homolog | KIAA1113 | KIAA1113 | Protein Rfg7 | RET-fused gene 7 protein | RFG7 | TIF1-gamma | TIF1G | TRI33_HUMAN | TRIM33 | Transcription intermediary factor 1-gamma | Tripartite motif-containing protein 33
Type:PROTEIN
Mol. Mass.:122534.89
Organism:Homo sapiens (Human)
Description:ChEMBL_105347
Residue:1127
Sequence:
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKI
EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI
YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM220447
n/a
NameBDBM220447
Synonyms:US10633379, Compound X | US9296741, 36
TypeSmall organic molecule
Emp. Form.C22H19F2N3O4S
Mol. Mass.459.466
SMILESCCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: