| Reaction Details |
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 | Report a problem with these data |
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Ligand | BDBM50241831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1670608 |
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| IC50 | 30±n/a nM |
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| Citation |  Fiorito, J; Vendome, J; Saeed, F; Staniszewski, A; Zhang, H; Yan, S; Deng, SX; Arancio, O; Landry, DW Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease. J Med Chem60:8858-8875 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) |
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| Type: | Protein |
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| Mol. Mass.: | 99132.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51160 |
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| Residue: | 858 |
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| Sequence: | MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
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| BDBM50241831 |
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| n/a |
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| Name | BDBM50241831 |
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| Synonyms: | CHEMBL4062273 | US10626113, Compound M | US10899756, Compound U |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21ClN4O2 |
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| Mol. Mass. | 420.891 |
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| SMILES | COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl |
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| Structure | 
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