| Reaction Details |
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 | Report a problem with these data |
| Target | Folylpolyglutamate synthase, mitochondrial |
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| Ligand | BDBM50002471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68676 (CHEMBL682447) |
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| Ki | 64±n/a nM |
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| Citation |  Singh, SK; Singer, SC; Ferone, R; Waters, KA; Mullin, RJ; Hynes, JB Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine. J Med Chem35:2002-6 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Folylpolyglutamate synthase, mitochondrial |
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| Name: | Folylpolyglutamate synthase, mitochondrial |
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| Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64621.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_68676 |
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| Residue: | 587 |
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| Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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| BDBM50002471 |
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| n/a |
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| Name | BDBM50002471 |
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| Synonyms: | 5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | 5-Amino-2-{4-[(2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | CHEMBL289923 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27N7O4 |
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| Mol. Mass. | 429.4729 |
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| SMILES | NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)[nH]c(=O)c3C2)cc1)C(O)=O |
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| Structure | 
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