Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCoagulation factor X
LigandBDBM50242360
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1671573 (CHEMBL4021602)
Ki 5800±n/a nM
Citation Wurtz, NRParkhurst, BLDeLucca, IGlunz, PWJiang, WZhang, XCheney, DLBozarth, JMRendina, ARWei, AHarper, TLuettgen, JMWu, YWong, PCSeiffert, DAWexler, RRPriestley, ES Neutral macrocyclic factor VIIa inhibitors. Bioorg Med Chem Lett27:2650-2654 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50242360
n/a
NameBDBM50242360
Synonyms:CHEMBL4069575
TypeSmall organic molecule
Emp. Form.C31H36N4O6S
Mol. Mass.592.706
SMILESCCc1cc2ccc1CCOC(=O)Nc1ccc(c(CN(C)C(=O)[C@@H]2Nc2cccc(c2)C(N)=O)c1)S(=O)(=O)C(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: