| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII |
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| Ligand | BDBM50242359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1671569 (CHEMBL4021598) |
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| Ki | 4.2±n/a nM |
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| Citation |  Wurtz, NR; Parkhurst, BL; DeLucca, I; Glunz, PW; Jiang, W; Zhang, X; Cheney, DL; Bozarth, JM; Rendina, AR; Wei, A; Harper, T; Luettgen, JM; Wu, Y; Wong, PC; Seiffert, DA; Wexler, RR; Priestley, ES Neutral macrocyclic factor VIIa inhibitors. Bioorg Med Chem Lett27:2650-2654 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor VII |
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| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM50242359 |
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| n/a |
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| Name | BDBM50242359 |
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| Synonyms: | CHEMBL4083729 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H34N4O6S |
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| Mol. Mass. | 614.711 |
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| SMILES | CN1Cc2cc(NC(=O)OCCc3c(C)cc(cc3C)[C@@H](Nc3ccc4cc[nH]c(=O)c4c3)C1=O)ccc2S(=O)(=O)C1CC1 |r| |
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| Structure | 
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