| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase MARK1 |
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| Ligand | BDBM50242512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1671754 (CHEMBL4021783) |
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| IC50 | >100000±n/a nM |
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| Citation |  Fischer, T; Krüger, T; Najjar, A; Totzke, F; Schächtele, C; Sippl, W; Ritter, C; Hilgeroth, A Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett27:2708-2712 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase MARK1 |
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| Name: | Serine/threonine-protein kinase MARK1 |
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| Synonyms: | KIAA1477 | MARK | MARK1 | MARK1_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 89034.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P0L2 |
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| Residue: | 795 |
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| Sequence: | MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY
RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV
KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH
RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV
WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG
SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE
VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR
RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP
ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV
ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD
RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF
VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE
IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI
AFKNIASKIANELKL
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| BDBM50242512 |
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| n/a |
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| Name | BDBM50242512 |
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| Synonyms: | CHEMBL4098682 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O |
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| Mol. Mass. | 333.3871 |
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| SMILES | Cc1ccc(CNc2nc(N)nc3[nH]c4cc(C)c(O)cc4c23)cc1 |
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| Structure | 
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