| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 21 |
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| Ligand | BDBM50242512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1671763 (CHEMBL4021792) |
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| IC50 | >100000±n/a nM |
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| Citation |  Fischer, T; Krüger, T; Najjar, A; Totzke, F; Schächtele, C; Sippl, W; Ritter, C; Hilgeroth, A Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett27:2708-2712 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 21 |
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| Name: | Mitogen-activated protein kinase kinase kinase 21 |
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| Synonyms: | 2.7.11.25 | KIAA1804 | M3K21_HUMAN | MAP3K21 | MLK4 | Mitogen-activated protein kinase kinase kinase 21 | Mitogen-activated protein kinase kinase kinase MLK4 | Mixed lineage kinase 4 | Synonyms=KIAA1804 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 113984.11 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_109906 |
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| Residue: | 1036 |
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| Sequence: | MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS
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| BDBM50242512 |
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| n/a |
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| Name | BDBM50242512 |
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| Synonyms: | CHEMBL4098682 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O |
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| Mol. Mass. | 333.3871 |
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| SMILES | Cc1ccc(CNc2nc(N)nc3[nH]c4cc(C)c(O)cc4c23)cc1 |
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| Structure | 
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