| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50242622 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1671985 (CHEMBL4022014) |
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| IC50 | <10000±n/a nM |
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| Citation |  Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1?/? inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorg Med Chem Lett27:2663-2667 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57124.52 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502245 |
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| Residue: | 483 |
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| Sequence: | MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESR
SINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRH
HTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH
KVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVF
ELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDY
TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCD
VWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDE
HSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLK
KHT
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| BDBM50242622 |
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| n/a |
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| Name | BDBM50242622 |
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| Synonyms: | CHEMBL4065204 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21N5O2 |
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| Mol. Mass. | 423.4665 |
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| SMILES | COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC |
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| Structure | 
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