| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
|---|
| Ligand | BDBM50242624 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1671985 (CHEMBL4022014) |
|---|
| IC50 | <10000±n/a nM |
|---|
| Citation |  Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1?/? inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorg Med Chem Lett27:2663-2667 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK1 |
|---|
| Name: | Dual specificity protein kinase CLK1 |
|---|
| Synonyms: | CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57124.52 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1502245 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESR
SINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRH
HTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH
KVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVF
ELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDY
TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCD
VWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDE
HSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLK
KHT
|
|
|
|---|
| BDBM50242624 |
|---|
| n/a |
|---|
| Name | BDBM50242624 |
|---|
| Synonyms: | CHEMBL4081787 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N5O3 |
|---|
| Mol. Mass. | 377.3966 |
|---|
| SMILES | COc1ccc(cc1)-c1cc(Nc2ncnc3cc(OC)c(OC)cc23)n[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
