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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM50242700
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1672106 (CHEMBL4022135)
IC50 8.0±n/a nM
Citation Smith, GFAltman, MDAndresen, BBaker, JBrubaker, JDChen, HChen, YChilders, MDonofrio, AFerguson, HFischer, CFischmann, TOGibeau, CHicks, AJin, SKattar, SKleinschek, MALeccese, ELesburg, CLi, CLim, JLiu, DMaclean, JKFMansoor, FMoy, LYMulrooney, EFNecheva, ASPresland, JRakhilina, LYang, RTorres, LZhang-Hoover, JNorthrup, A Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett27:2721-2726 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM50242700
n/a
NameBDBM50242700
Synonyms:CHEMBL4088745 | US9932350, 3-20
TypeSmall organic molecule
Emp. Form.C20H26N6O2S
Mol. Mass.414.524
SMILESCS(=O)(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:13.17,wD:10.10,(38.83,-2.39,;37.49,-1.61,;36.72,-.27,;38.26,-.27,;36.16,-2.38,;36.15,-3.92,;34.83,-4.69,;33.5,-3.92,;33.49,-2.38,;34.83,-1.61,;32.17,-4.69,;30.83,-3.92,;29.49,-4.69,;29.51,-6.23,;30.84,-7,;32.17,-6.23,;28.18,-7,;28.19,-8.54,;29.52,-9.3,;29.53,-10.85,;28.2,-11.62,;26.86,-10.86,;25.53,-11.63,;24.19,-10.86,;24.2,-9.32,;25.53,-8.55,;26.86,-9.31,;22.86,-8.55,;21.52,-7.78,)|
Structure
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