Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50003204

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_47804

IC50

0.029000±n/a nM

Citation

Tilley, JW; Danho, W; Shiuey, SJ; Kulesha, I; Swistok, J; Makofske, R; Michalewsky, J; Triscari, J; Nelson, D; Weatherford, S Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29. J Med Chem35:3774-83 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

CCKBR | Cholecystokinin B receptor | GASR_BOVIN

Type:

PROTEIN

Mol. Mass.:

48807.54

Organism:

Bos taurus

Description:

ChEMBL_48437

Residue:

454

Sequence:

MELLKPNRSVLGSGPGPGASLCRSGGPLLNGSGTGNLSCEPPRIRGAGTRELELAIRVTL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVVCKAVSYFMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWM
LSGLLMVPYPVYTAVQPAGPRVLQCMHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYGL
ISRELYLGLRFDGDSDSESQSRVGSQGGLPGGTGQGPAQANGRCRSETRLAGEDGDGCYV
QLPRSRPALEMSALTAPTPGPGSGTRPAQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSAN
TWRAFDGPGAHRALSGAPISFIHLLTYASACVNPLVYCFMHRRFRQACLDTCTRCCPRPP
RARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50003204

n/a

Name

BDBM50003204

Synonyms:

CHEMBL122438 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2-[2-(2-{2-[2-carboxyamino-3-(4-sulfo-phenyl)-propionylamino]-cyclopentyl}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-succinamic acid

Type

Small organic molecule

Emp. Form.

C46H56N8O13S2

Mol. Mass.

993.113

SMILES

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

Structure