| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50003360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138799 (CHEMBL751535) |
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| IC50 | 65±n/a nM |
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| Citation |  Ward, JS; Merritt, L; Klimkowski, VJ; Lamb, ML; Mitch, CH; Bymaster, FP; Sawyer, B; Shannon, HE; Olesen, PH; Honoré, T Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. J Med Chem35:4011-9 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50003360 |
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| n/a |
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| Name | BDBM50003360 |
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| Synonyms: | 2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-propoxy-pyrazine | CHEMBL132272 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H19N3O |
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| Mol. Mass. | 233.3095 |
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| SMILES | CCCOc1nccnc1C1=CCCN(C)C1 |t:11| |
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| Structure | 
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