Reaction Details |
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Target | Polyunsaturated fatty acid 5-lipoxygenase |
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Ligand | BDBM50003458 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_3958 |
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IC50 | 250±n/a nM |
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Citation | Wright, SW; Harris, RR; Kerr, JS; Green, AM; Pinto, DJ; Bruin, EM; Collins, RJ; Dorow, RL; Mantegna, LR; Sherk, SR Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis. J Med Chem35:4061-8 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid 5-lipoxygenase |
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Name: | Polyunsaturated fatty acid 5-lipoxygenase |
Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
Type: | PROTEIN |
Mol. Mass.: | 78082.31 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1432947 |
Residue: | 673 |
Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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BDBM50003458 |
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n/a |
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Name | BDBM50003458 |
Synonyms: | (Z)-3-(Benzyl-hydroxy-amino)-1-(4-fluoro-phenyl)-but-2-en-1-one | 3-(Benzyl-hydroxy-amino)-1-(4-fluoro-phenyl)-but-2-en-1-one | CHEMBL11871 |
Type | Small organic molecule |
Emp. Form. | C17H16FNO2 |
Mol. Mass. | 285.3128 |
SMILES | CC(=CC(=O)c1ccc(F)cc1)N(O)Cc1ccccc1 |w:2.2| |
Structure |
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