| Reaction Details |
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 | Report a problem with these data |
| Target | Acidic mammalian chitinase |
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| Ligand | BDBM50243760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1672910 (CHEMBL4022939) |
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| IC50 | 8.7±n/a nM |
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| Citation |  Mazur, M; Olczak, J; Olejniczak, S; Koralewski, R; Czestkowski, W; Jedrzejczak, A; Golab, J; Dzwonek, K; Dymek, B; Sklepkiewicz, PL; Zagozdzon, A; Noonan, T; Mahboubi, K; Conway, B; Sheeler, R; Beckett, P; Hungerford, WM; Podjarny, A; Mitschler, A; Cousido-Siah, A; Fadel, F; Golebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem61:695-710 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acidic mammalian chitinase |
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| Name: | Acidic mammalian chitinase |
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| Synonyms: | AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902 |
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| Type: | Protein |
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| Mol. Mass.: | 52266.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BZP6 |
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| Residue: | 476 |
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| Sequence: | MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
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| BDBM50243760 |
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| n/a |
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| Name | BDBM50243760 |
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| Synonyms: | CHEMBL4082060 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H33ClN6 |
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| Mol. Mass. | 416.991 |
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| SMILES | Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)CC1CCCCC1 |
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| Structure | 
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