| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 9 |
|---|
| Ligand | BDBM50163863 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1673888 (CHEMBL4023917) |
|---|
| KOFF | 1.4 s-1 |
|---|
| Citation |  Linkuvien?, V; Talibov, VO; Danielson, UH; Matulis, D Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design. J Med Chem61:2292-2302 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 9 |
|---|
| Name: | Carbonic anhydrase 9 |
|---|
| Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49669.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 459 |
|---|
| Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
|---|
| BDBM50163863 |
|---|
| n/a |
|---|
| Name | BDBM50163863 |
|---|
| Synonyms: | 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide (2a) | CHEMBL3798446 | carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12ClN3O3S |
|---|
| Mol. Mass. | 349.792 |
|---|
| SMILES | NS(=O)(=O)c1ccc(cc1Cl)C(=O)Cn1cnc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
