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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3
LigandBDBM50244894
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1674279 (CHEMBL4024308)
IC50 11±n/a nM
Citation Li, YLuo, XGuo, QNie, YWang, TZhang, CHuang, ZWang, XLiu, YChen, YZheng, JYang, SFan, YXiang, R Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer. J Med Chem61:3166-3192 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3
Name:Cyclin-dependent kinase 4/G1/S-specific cyclin-D3
Synonyms:CDK4/Cyclin D3
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1806445
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 4
Synonyms:CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:Enzyme Subunit
Mol. Mass.:33731.96
Organism:Homo sapiens (Human)
Description:P11802
Residue:303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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Component 2
Name:G1/S-specific cyclin-D3
Synonyms:CCND3 | CCND3_HUMAN
Type:Enzyme
Mol. Mass.:32521.90
Organism:Homo sapiens (Human)
Description:P30281
Residue:292
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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BDBM50244894
n/a
NameBDBM50244894
Synonyms:CHEMBL4090436
TypeSmall organic molecule
Emp. Form.C26H33N7O4
Mol. Mass.507.5847
SMILESCN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCC(=O)NO)cc3)nc2n1C1CCCC1
Structure
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