| Reaction Details |
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 | Report a problem with these data |
| Target | DCN1-like protein 1 |
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| Ligand | BDBM50245225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1674520 (CHEMBL4024549) |
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| IC50 | 50±n/a nM |
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| Citation |  Hammill, JT; Bhasin, D; Scott, DC; Min, J; Chen, Y; Lu, Y; Yang, L; Kim, HS; Connelly, MC; Hammill, C; Holbrook, G; Jeffries, C; Singh, B; Schulman, BA; Guy, RK Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem61:2694-2706 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DCN1-like protein 1 |
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| Name: | DCN1-like protein 1 |
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| Synonyms: | DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30118.96 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117443 |
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| Residue: | 259 |
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| Sequence: | MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSL
DRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQ
EFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA
YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLI
DDFVEFARPQIAGTKSTTV
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| BDBM50245225 |
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| n/a |
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| Name | BDBM50245225 |
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| Synonyms: | CHEMBL4099097 | US11116757, No. A15 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32F3N3O |
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| Mol. Mass. | 447.5363 |
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| SMILES | CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F |
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| Structure | 
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