| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50245493 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1674759 (CHEMBL4024902) |
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| IC50 | 27±n/a nM |
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| Citation |  Liu, YM; Nepali, K; Liou, JP Idiopathic Pulmonary Fibrosis: Current Status, Recent Progress, and Emerging Targets. J Med Chem60:527-553 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50245493 |
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| n/a |
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| Name | BDBM50245493 |
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| Synonyms: | CHEMBL4092255 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H52N6O6 |
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| Mol. Mass. | 664.8347 |
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| SMILES | COc1ccc2c(O[C@@H]3C[C@@H](N(C[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)C3)C(=O)N[C@@H](CC3CC3)C(=O)C(=O)NC3CC3)nccc2c1 |r| |
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| Structure | 
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