Reaction Details |
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Target | Cytoplasmic tyrosine-protein kinase BMX |
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Ligand | BDBM50161162 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1674789 (CHEMBL4024932) |
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IC50 | 2665±n/a nM |
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Citation | Liang, Q; Chen, Y; Yu, K; Chen, C; Zhang, S; Wang, A; Wang, W; Wu, H; Liu, X; Wang, B; Wang, L; Hu, Z; Wang, W; Ren, T; Zhang, S; Liu, Q; Yun, CH; Liu, J Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem131:107-125 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytoplasmic tyrosine-protein kinase BMX |
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Name: | Cytoplasmic tyrosine-protein kinase BMX |
Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
Type: | Tyrosine-protein kinase |
Mol. Mass.: | 78030.42 |
Organism: | Homo sapiens (Human) |
Description: | P51813 |
Residue: | 675 |
Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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BDBM50161162 |
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n/a |
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Name | BDBM50161162 |
Synonyms: | AVL-292 | CC-292 | Spebrutinib | US10596172, Compound I-182 | US10828300, Compound I-182 | US11351168, Compound I-182 | US9987276, Compound I-182 |
Type | Small organic molecule |
Emp. Form. | C22H22FN5O3 |
Mol. Mass. | 423.4402 |
SMILES | COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1 |
Structure |
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