| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
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| Ligand | BDBM50243294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1676359 (CHEMBL4026502) |
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| IC50 | 63±n/a nM |
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| Citation |  Wang, C; Jiang, H; Jin, J; Xie, Y; Chen, Z; Zhang, H; Lian, F; Liu, YC; Zhang, C; Ding, H; Chen, S; Zhang, N; Zhang, Y; Jiang, H; Chen, K; Ye, F; Yao, Z; Luo, C Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation. J Med Chem60:8888-8905 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-arginine methyltransferase CARM1 |
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| Name: | Histone-arginine methyltransferase CARM1 |
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| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
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| Type: | Protein |
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| Mol. Mass.: | 65855.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86X55 |
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| Residue: | 608 |
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| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
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| BDBM50243294 |
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| n/a |
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| Name | BDBM50243294 |
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| Synonyms: | CHEMBL4094513 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19ClN2S |
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| Mol. Mass. | 306.853 |
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| SMILES | CN(CCN)Cc1ccccc1Sc1ccccc1Cl |
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| Structure | 
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