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TargetHistone-arginine methyltransferase CARM1
LigandBDBM50243294
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1676359
IC50 63±n/a nM
Citation Wang CJiang HJin JXie YChen ZZhang HLian FLiu YCZhang CDing HChen SZhang NZhang YJiang HChen KYe FYao ZLuo C Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation. J Med Chem 60:8888-8905 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone-arginine methyltransferase CARM1
Name:Histone-arginine methyltransferase CARM1
Synonyms:CARM1 | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4)
Type:Protein
Mol. Mass.:65855.47
Organism:Homo sapiens (Human)
Description:n/a
Residue:608
Sequence:
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
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  Blast E-value cutoff:
BDBM50243294
n/a
NameBDBM50243294
Synonyms:CHEMBL4094513
TypeSmall organic molecule
Emp. Form.C16H19ClN2S
Mol. Mass.306.853
SMILESCN(CCN)Cc1ccccc1Sc1ccccc1Cl
Structure
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