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TargetProtein arginine N-methyltransferase 1
LigandBDBM50243294
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1676354
IC50 1.1±n/a nM
Citation Wang CJiang HJin JXie YChen ZZhang HLian FLiu YCZhang CDing HChen SZhang NZhang YJiang HChen KYe FYao ZLuo C Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation. J Med Chem 60:8888-8905 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 1
Name:Protein arginine N-methyltransferase 1
Synonyms:Histone-arginine N-methyltransferase PRMT1 | Hrmt1l2 | Prmt1
Type:PROTEIN
Mol. Mass.:40514.94
Organism:Rattus norvegicus
Description:ChEMBL_103589
Residue:353
Sequence:
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRN
SMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHV
VTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATL
YVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIY
TVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFY
MEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
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  Blast E-value cutoff:
BDBM50243294
n/a
NameBDBM50243294
Synonyms:CHEMBL4094513
TypeSmall organic molecule
Emp. Form.C16H19ClN2S
Mol. Mass.306.853
SMILESCN(CCN)Cc1ccccc1Sc1ccccc1Cl
Structure
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