| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
|---|
| Ligand | BDBM50246076 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1676417 (CHEMBL4026560) |
|---|
| IC50 | 1100±n/a nM |
|---|
| Citation |  Fujimoto, J; Okamoto, R; Noguchi, N; Hara, R; Masada, S; Kawamoto, T; Nagase, H; Tamura, YO; Imanishi, M; Takagahara, S; Kubo, K; Tohyama, K; Iida, K; Andou, T; Miyahisa, I; Matsui, J; Hayashi, R; Maekawa, T; Matsunaga, N Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available?-5 Desaturase (D5D) Inhibitors. J Med Chem60:8963-8981 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA (8-3)-desaturase |
|---|
| Name: | Acyl-CoA (8-3)-desaturase |
|---|
| Synonyms: | FADS1 | FADS1_HUMAN | FADSD5 | Fatty acid desaturase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 51985.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1513296 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
|
|
|
|---|
| BDBM50246076 |
|---|
| n/a |
|---|
| Name | BDBM50246076 |
|---|
| Synonyms: | CHEMBL4063561 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H13Cl2NO3 |
|---|
| Mol. Mass. | 338.185 |
|---|
| SMILES | Oc1cc(CN2CC(OC2=O)c2ccccc2)c(Cl)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
