| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-arginine deiminase type-2 |
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| Ligand | BDBM50246179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1676559 (CHEMBL4026702) |
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| Ki | >10000000±n/a nM |
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| Citation |  Tejeda, EJC; Bello, AM; Wasilewski, E; Koebel, A; Dunn, S; Kotra, LP Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis. J Med Chem60:8876-8887 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-arginine deiminase type-2 |
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| Name: | Protein-arginine deiminase type-2 |
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| Synonyms: | 3.5.3.15 | PADI2_MOUSE | Pad2 | Padi2 | Pdi | Pdi2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II | Protein-arginine deiminase type-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76237.59 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_105600 |
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| Residue: | 673 |
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| Sequence: | MQPPIRENMLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAGAKTFSLKHSEGVKVEV
VRDGEAEEVVTNGKQRWALSPSSTLRLSMAQASTEASSDKVTVNYYEEEGSAPIDQAGLF
LTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILLVNCDRDTPWLPKEDCSDEKV
YSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGR
QKLYHVVKYTGGSAELLFFVEGLCFPDESFSGLVSIHVSLLEYMAEGIPLTPIFTDTVMF
RIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYMNRGDRWIQDE
IEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQLLGPDFGYVTREPLFETVTSLDSFGNLE
VSPPVTVNGKEYPLGRILIGSSFPLSGGRRMTKVVRDFLQAQQVQAPVELYSDWLTVGHV
DEFMTFIPIPGKKEFRLLMASTSACYQLFREKQKAGHGEAVMFKGLGGMSSKRITINKIL
SNESLTQENQYFQRCLDWNRDILKRELALTEKDIIDLPALFKMDENHQARAFFPNMVNMI
VLDKDLGIPKPFGPQVEEECCLETHVRGLLEPLGLACTFIDDISAYHKFLGEVHCGTNVR
RKPFTFKWWHMVP
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| BDBM50246179 |
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| n/a |
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| Name | BDBM50246179 |
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| Synonyms: | CHEMBL4081389 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O3 |
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| Mol. Mass. | 352.3871 |
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| SMILES | O=C(NCc1ccccc1)[C@H](CCn1ccnc1)NC(=O)c1ccco1 |r| |
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| Structure | 
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