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TargetHistone deacetylase 8
LigandBDBM50246848
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1677037 (CHEMBL4027180)
IC50 72±n/a nM
Citation Heimburg, TKolbinger, FRZeyen, PGhazy, EHerp, DSchmidtkunz, KMelesina, JShaik, TBErdmann, FSchmidt, MRomier, CRobaa, DWitt, OOehme, IJung, MSippl, W Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. J Med Chem60:10188-10204 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 8
Name:Histone deacetylase 8
Synonyms:HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:Enzyme
Mol. Mass.:41749.60
Organism:Homo sapiens (Human)
Description:Q9BY41
Residue:377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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  Blast E-value cutoff:
BDBM50246848
n/a
NameBDBM50246848
Synonyms:CHEMBL4061831
TypeSmall organic molecule
Emp. Form.C14H13FN2O2
Mol. Mass.260.2636
SMILESONC(=O)c1ccc(F)c(NCc2ccccc2)c1
Structure
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