Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50246848 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1677037 (CHEMBL4027180) |
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IC50 | 72±n/a nM |
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Citation | Heimburg, T; Kolbinger, FR; Zeyen, P; Ghazy, E; Herp, D; Schmidtkunz, K; Melesina, J; Shaik, TB; Erdmann, F; Schmidt, M; Romier, C; Robaa, D; Witt, O; Oehme, I; Jung, M; Sippl, W Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. J Med Chem60:10188-10204 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50246848 |
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n/a |
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Name | BDBM50246848 |
Synonyms: | CHEMBL4061831 |
Type | Small organic molecule |
Emp. Form. | C14H13FN2O2 |
Mol. Mass. | 260.2636 |
SMILES | ONC(=O)c1ccc(F)c(NCc2ccccc2)c1 |
Structure |
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