| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50246874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1677037 (CHEMBL4027180) |
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| IC50 | 38±n/a nM |
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| Citation |  Heimburg, T; Kolbinger, FR; Zeyen, P; Ghazy, E; Herp, D; Schmidtkunz, K; Melesina, J; Shaik, TB; Erdmann, F; Schmidt, M; Romier, C; Robaa, D; Witt, O; Oehme, I; Jung, M; Sippl, W Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. J Med Chem60:10188-10204 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50246874 |
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| n/a |
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| Name | BDBM50246874 |
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| Synonyms: | CHEMBL4095643 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13ClN2O4 |
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| Mol. Mass. | 320.728 |
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| SMILES | COc1ccc(cc1C(=O)Nc1ccc(Cl)cc1)C(=O)NO |
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| Structure | 
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