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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
LigandBDBM50246909
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1677120 (CHEMBL4027263)
IC50>30000±n/a nM
Citation Carzaniga, LAmari, GRizzi, ACapaldi, CDe Fanti, RGhidini, EVilletti, GCarnini, CMoretto, NFacchinetti, FCaruso, PMarchini, GBattipaglia, LPatacchini, RCenacchi, VVolta, RAmadei, FPappani, ACapacchi, SBagnacani, VDelcanale, MPuccini, PCatinella, SCivelli, MArmani, E Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases. J Med Chem60:10026-10046 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Name:Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Synonyms:Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A
Type:Enzyme
Mol. Mass.:104751.53
Organism:Homo sapiens (Human)
Description:Q9HCR9
Residue:933
Sequence:
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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  Blast E-value cutoff:
BDBM50246909
n/a
NameBDBM50246909
Synonyms:CHEMBL4075951
TypeSmall organic molecule
Emp. Form.C31H31Cl2F2N3O8S2
Mol. Mass.746.626
SMILESCN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r|
Structure
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