Reaction Details |
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Target | Protein arginine N-methyltransferase 3 |
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Ligand | BDBM50247356 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1677669 (CHEMBL4027812) |
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IC50 | 967±n/a nM |
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Citation | Kaniskan, HÜ; Eram, MS; Zhao, K; Szewczyk, MM; Yang, X; Schmidt, K; Luo, X; Xiao, S; Dai, M; He, F; Zang, I; Lin, Y; Li, F; Dobrovetsky, E; Smil, D; Min, SJ; Lin-Jones, J; Schapira, M; Atadja, P; Li, E; Barsyte-Lovejoy, D; Arrowsmith, CH; Brown, PJ; Liu, F; Yu, Z; Vedadi, M; Jin, J Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J Med Chem61:1204-1217 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 3 |
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Name: | Protein arginine N-methyltransferase 3 |
Synonyms: | 2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 |
Type: | PROTEIN |
Mol. Mass.: | 59886.87 |
Organism: | Homo sapiens |
Description: | ChEMBL_101368 |
Residue: | 531 |
Sequence: | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
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BDBM50247356 |
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n/a |
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Name | BDBM50247356 |
Synonyms: | CHEMBL4068520 |
Type | Small organic molecule |
Emp. Form. | C16H19N5O2 |
Mol. Mass. | 313.3544 |
SMILES | O=C(NCC(=O)N1CCCCC1)Nc1ccc2cncnc2c1 |
Structure |
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