| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase subunit M2 |
|---|
| Ligand | BDBM50247408 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1677703 (CHEMBL4027846) |
|---|
| IC50 | 123000±n/a nM |
|---|
| Citation |  Huff, SE; Mohammed, FA; Yang, M; Agrawal, P; Pink, J; Harris, ME; Dealwis, CG; Viswanathan, R Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem61:666-680 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ribonucleoside-diphosphate reductase subunit M2 |
|---|
| Name: | Ribonucleoside-diphosphate reductase subunit M2 |
|---|
| Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44868.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_195255 |
|---|
| Residue: | 389 |
|---|
| Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
|
|
|
|---|
| BDBM50247408 |
|---|
| n/a |
|---|
| Name | BDBM50247408 |
|---|
| Synonyms: | CHEMBL4067105 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14N2O3 |
|---|
| Mol. Mass. | 306.3154 |
|---|
| SMILES | Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
