| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase large subunit |
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| Ligand | BDBM50247424 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1677693 (CHEMBL4027836) |
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| IC50 | 21500±n/a nM |
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| Citation |  Huff, SE; Mohammed, FA; Yang, M; Agrawal, P; Pink, J; Harris, ME; Dealwis, CG; Viswanathan, R Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem61:666-680 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonucleoside-diphosphate reductase large subunit |
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| Name: | Ribonucleoside-diphosphate reductase large subunit |
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| Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90074.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_90946 |
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| Residue: | 792 |
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| Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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| BDBM50247424 |
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| n/a |
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| Name | BDBM50247424 |
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| Synonyms: | CHEMBL4101599 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13BrN2O |
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| Mol. Mass. | 341.202 |
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| SMILES | Oc1ccc2ccccc2c1\C=N\Nc1ccc(Br)cc1 |
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| Structure | 
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