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TargetRibonucleoside-diphosphate reductase large subunit
LigandBDBM50247435
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1677693 (CHEMBL4027836)
IC50 6100±n/a nM
Citation Huff, SEMohammed, FAYang, MAgrawal, PPink, JHarris, MEDealwis, CGViswanathan, R Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem61:666-680 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ribonucleoside-diphosphate reductase large subunit
Name:Ribonucleoside-diphosphate reductase large subunit
Synonyms:RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit
Type:PROTEIN
Mol. Mass.:90074.67
Organism:Homo sapiens (Human)
Description:ChEMBL_90946
Residue:792
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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  Blast E-value cutoff:
BDBM50247435
n/a
NameBDBM50247435
Synonyms:CHEMBL4073197
TypeSmall organic molecule
Emp. Form.C18H14ClN3O2
Mol. Mass.339.776
SMILESNc1ccc(cc1Cl)C(=O)N\N=C\c1c(O)ccc2ccccc12
Structure
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