Reaction Details |
| Report a problem with these data |
Target | Ribonucleoside-diphosphate reductase large subunit |
---|
Ligand | BDBM50247438 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1677693 (CHEMBL4027836) |
---|
IC50 | 297700±n/a nM |
---|
Citation | Huff, SE; Mohammed, FA; Yang, M; Agrawal, P; Pink, J; Harris, ME; Dealwis, CG; Viswanathan, R Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem61:666-680 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ribonucleoside-diphosphate reductase large subunit |
---|
Name: | Ribonucleoside-diphosphate reductase large subunit |
Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
Type: | PROTEIN |
Mol. Mass.: | 90074.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_90946 |
Residue: | 792 |
Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
|
|
|
BDBM50247438 |
---|
n/a |
---|
Name | BDBM50247438 |
Synonyms: | CHEMBL4084809 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O4S |
Mol. Mass. | 400.491 |
SMILES | CC1(C)C2CC(CS(=O)(=O)N\N=C\c3c(O)ccc4ccccc34)C1C(=O)C2 |TLB:26:25:1:5.4,6:5:1:27.25| |
Structure |
|