Reaction Details |
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Target | Adenosine receptor A3 |
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Ligand | BDBM50247453 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1677778 (CHEMBL4027921) |
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Ki | 1100±n/a nM |
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Citation | Petrelli, R; Scortichini, M; Belardo, C; Boccella, S; Luongo, L; Capone, F; Kachler, S; Vita, P; Del Bello, F; Maione, S; Lavecchia, A; Klotz, KN; Cappellacci, L Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A J Med Chem61:305-318 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Adenosine receptor A3 |
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Name: | Adenosine receptor A3 |
Synonyms: | A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 36197.32 |
Organism: | Homo sapiens (Human) |
Description: | P0DMS8 |
Residue: | 318 |
Sequence: | MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE
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BDBM50247453 |
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n/a |
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Name | BDBM50247453 |
Synonyms: | CHEMBL4103712 |
Type | Small organic molecule |
Emp. Form. | C14H17Cl2N5O4 |
Mol. Mass. | 390.222 |
SMILES | O[C@@H]1[C@@H](CCl)O[C@H]([C@@H]1O)n1cnc2c(N[C@@H]3CCOC3)nc(Cl)nc12 |r| |
Structure |
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