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TargetC-X-C chemokine receptor type 4
LigandBDBM50247610
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1678192 (CHEMBL4028335)
IC50 34±n/a nM
Citation Wu, CHSong, JSKuan, HHWu, SHChou, MCJan, JJTsou, LKKe, YYChen, CTYeh, KCWang, SYYeh, TKTseng, CTHuang, CLWu, MHKuo, PCLee, CJShia, KS Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond. J Med Chem61:818-833 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 4
Name:C-X-C chemokine receptor type 4
Synonyms:C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Type:Enzyme
Mol. Mass.:39754.61
Organism:Homo sapiens (Human)
Description:P61073
Residue:352
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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  Blast E-value cutoff:
BDBM50247610
n/a
NameBDBM50247610
Synonyms:CHEMBL4070263
TypeSmall organic molecule
Emp. Form.C24H42N10
Mol. Mass.470.6573
SMILESC(CNCCCn1cc(CNc2nccc(NC3CCNCC3)n2)nn1)CNC1CCCCC1
Structure
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