| Reaction Details |
|---|
 | Report a problem with these data |
| Target | N-lysine methyltransferase SMYD2 |
|---|
| Ligand | BDBM50247634 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1678260 (CHEMBL4028403) |
|---|
| IC50 | 62000±n/a nM |
|---|
| Citation |  Babault, N; Allali-Hassani, A; Li, F; Fan, J; Yue, A; Ju, K; Liu, F; Vedadi, M; Liu, J; Jin, J Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). J Med Chem61:1541-1551 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| N-lysine methyltransferase SMYD2 |
|---|
| Name: | N-lysine methyltransferase SMYD2 |
|---|
| Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49689.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NRG4 |
|---|
| Residue: | 433 |
|---|
| Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
|
|
|
|---|
| BDBM50247634 |
|---|
| n/a |
|---|
| Name | BDBM50247634 |
|---|
| Synonyms: | CHEMBL4067973 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H32N8O6 |
|---|
| Mol. Mass. | 528.5609 |
|---|
| SMILES | N[C@@H](CCCN(CCc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
