| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50004811 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63062 |
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| Ki | 0.213000±n/a nM |
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| Citation |  Mach, RH; Jackson, JR; Luedtke, RR; Ivins, KJ; Molinoff, PB; Ehrenkaufer, RL Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. J Med Chem35:423-30 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50004811 |
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| n/a |
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| Name | BDBM50004811 |
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| Synonyms: | 8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-(4-iodo-benzyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | CHEMBL335714 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31FIN3O2 |
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| Mol. Mass. | 611.4889 |
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| SMILES | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CN(Cc1ccc(I)cc1)C2=O)c1ccccc1 |
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| Structure | 
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