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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | ATP-binding cassette sub-family C member 3 | ||
| Ligand | BDBM50008923 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1678646 (CHEMBL4028923) | ||
| IC50 | >133000±n/a nM | ||
| Citation |  Morgan, RE; van Staden, CJ; Chen, Y; Kalyanaraman, N; Kalanzi, J; Dunn, RT; Afshari, CA; Hamadeh, HK A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci136:216-41 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| ATP-binding cassette sub-family C member 3 | |||
| Name: | ATP-binding cassette sub-family C member 3 | ||
| Synonyms: | ABCC3 | ATP-binding cassette sub-family C member 3 | CMOAT2 | Canalicular multispecific organic anion transporter 2 | MLP2 | MOAT-D | MRP3 | MRP3_HUMAN | Multi-specific organic anion transporter D | Multidrug resistance-associated protein 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 169352.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_735421 | ||
| Residue: | 1527 | ||
| Sequence: |
| ||
| BDBM50008923 | |||
| n/a | |||
| Name | BDBM50008923 | ||
| Synonyms: | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT) | 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | CHEMBL65 | Camptothecin (CT) | camptothecine | cid_24360 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H16N2O4 | ||
| Mol. Mass. | 348.352 | ||
| SMILES | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r| | ||
| Structure | 
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