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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 8 | ||
| Ligand | BDBM50040806 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1679209 (CHEMBL4029486) | ||
| IC50 | 22±n/a nM | ||
| Citation |  Ono, K; Banno, H; Okaniwa, M; Hirayama, T; Iwamura, N; Hikichi, Y; Murai, S; Hasegawa, M; Hasegawa, Y; Yonemori, K; Hata, A; Aoyama, K; Cary, DR Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives. Bioorg Med Chem25:2336-2350 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 8 | |||
| Name: | Cyclin-dependent kinase 8 | ||
| Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 53300.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P49336 | ||
| Residue: | 464 | ||
| Sequence: |
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| BDBM50040806 | |||
| n/a | |||
| Name | BDBM50040806 | ||
| Synonyms: | CHEMBL3361254 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H28N4O3S | ||
| Mol. Mass. | 416.537 | ||
| SMILES | NC(=O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@@H](CC4)N4CCOCC4)c3c12 |r,wU:18.21,wD:15.14,4.3,(33.74,-8.14,;32.23,-8.45,;31.75,-9.91,;31.21,-7.3,;31.69,-5.84,;33.16,-5.37,;33.17,-3.83,;31.7,-3.35,;30.79,-2.1,;29.32,-2.58,;27.99,-1.82,;26.66,-2.58,;26.66,-4.13,;27.99,-4.9,;27.99,-6.43,;26.66,-7.2,;25.33,-6.43,;24,-7.19,;23.99,-8.73,;25.32,-9.5,;26.66,-8.74,;22.66,-9.49,;21.33,-8.71,;20,-9.47,;19.98,-11,;21.31,-11.78,;22.65,-11.02,;29.32,-4.13,;30.79,-4.59,)| | ||
| Structure | 
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