Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-C/Cyclin-dependent kinase 19
LigandBDBM50248676
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1679275 (CHEMBL4029552)
IC50 15±n/a nM
Citation Ono, KBanno, HOkaniwa, MHirayama, TIwamura, NHikichi, YMurai, SHasegawa, MHasegawa, YYonemori, KHata, AAoyama, KCary, DR Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives. Bioorg Med Chem25:2336-2350 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-C/Cyclin-dependent kinase 19
Name:Cyclin-C/Cyclin-dependent kinase 19
Synonyms:CDK19/Cyclin C
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 19
Synonyms:CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028
Type:Serine/Threonine protein kinase
Mol. Mass.:56816.68
Organism:Homo sapiens (Human)
Description:Q9BWU1
Residue:502
Sequence:
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
LGYSSSSQQSSQYHPSHQAHRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Cyclin-C
Synonyms:CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:PROTEIN
Mol. Mass.:33244.88
Organism:Homo sapiens (Human)
Description:ChEMBL_107900
Residue:283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50248676
n/a
NameBDBM50248676
Synonyms:CHEMBL4065027
TypeSmall organic molecule
Emp. Form.C14H11N3O2S3
Mol. Mass.349.451
SMILESCSc1sc(C(=O)Nc2ccon2)c2CCc3cnsc3-c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: