| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-arginine deiminase type-1 |
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| Ligand | BDBM50248814 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1679372 (CHEMBL4029649) |
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| Ki | 2417000±n/a nM |
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| Citation |  Sarswat, A; Wasilewski, E; Chakka, SK; Bello, AM; Caprariello, AV; Muthuramu, CM; Stys, PK; Dunn, SE; Kotra, LP Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorg Med Chem25:2643-2656 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-arginine deiminase type-1 |
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| Name: | Protein-arginine deiminase type-1 |
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| Synonyms: | PAD1 | PADI1 | PADI1_HUMAN | PDI1 | Peptidylarginine deiminase I | Protein-arginine deiminase type I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74664.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290380 |
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| Residue: | 663 |
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| Sequence: | MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVK
EPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLE
VDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDM
SPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVER
QPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNT
QPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIE
APHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTV
GGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFV
PTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDN
LHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPK
PYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWN
MVP
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| BDBM50248814 |
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| n/a |
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| Name | BDBM50248814 |
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| Synonyms: | CHEMBL4070114 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N4O2 |
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| Mol. Mass. | 236.2703 |
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| SMILES | Cc1nccn1CCN1C(=O)NC(C)(C)C1=O |
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| Structure | 
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