Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProtein-arginine deiminase type-2
LigandBDBM50248830
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1679370 (CHEMBL4029647)
Ki 4621000±n/a nM
Citation Sarswat, AWasilewski, EChakka, SKBello, AMCaprariello, AVMuthuramu, CMStys, PKDunn, SEKotra, LP Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorg Med Chem25:2643-2656 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-arginine deiminase type-2
Name:Protein-arginine deiminase type-2
Synonyms:3.5.3.15 | PADI2_MOUSE | Pad2 | Padi2 | Pdi | Pdi2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II | Protein-arginine deiminase type-2
Type:PROTEIN
Mol. Mass.:76237.59
Organism:Mus musculus
Description:ChEMBL_105600
Residue:673
Sequence:
MQPPIRENMLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAGAKTFSLKHSEGVKVEV
VRDGEAEEVVTNGKQRWALSPSSTLRLSMAQASTEASSDKVTVNYYEEEGSAPIDQAGLF
LTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILLVNCDRDTPWLPKEDCSDEKV
YSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGR
QKLYHVVKYTGGSAELLFFVEGLCFPDESFSGLVSIHVSLLEYMAEGIPLTPIFTDTVMF
RIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYMNRGDRWIQDE
IEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQLLGPDFGYVTREPLFETVTSLDSFGNLE
VSPPVTVNGKEYPLGRILIGSSFPLSGGRRMTKVVRDFLQAQQVQAPVELYSDWLTVGHV
DEFMTFIPIPGKKEFRLLMASTSACYQLFREKQKAGHGEAVMFKGLGGMSSKRITINKIL
SNESLTQENQYFQRCLDWNRDILKRELALTEKDIIDLPALFKMDENHQARAFFPNMVNMI
VLDKDLGIPKPFGPQVEEECCLETHVRGLLEPLGLACTFIDDISAYHKFLGEVHCGTNVR
RKPFTFKWWHMVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50248830
n/a
NameBDBM50248830
Synonyms:CHEMBL4089583
TypeSmall organic molecule
Emp. Form.C10H14N4O2
Mol. Mass.222.2438
SMILESCC1(C)NC(=O)N(CCn2ccnc2)C1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: