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TargetSerine/threonine-protein kinase pim-3
LigandBDBM50387298
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1679429
IC50 1.9±n/a nM
Citation Bataille CJBrennan MBByrne SDavies SGDurbin MFedorov OHuber KVJones AMKnapp SLiu GNadali AQuevedo CERussell AJWalker RGWestwood RWynne GM Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family. Bioorg Med Chem 25:2657-2665 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-3
Name:Serine/threonine-protein kinase pim-3
Synonyms:Serine/threonine-protein kinase pim-3 (PIM3)
Type:Protein
Mol. Mass.:35888.19
Organism:Homo sapiens (Human)
Description:Q86V86
Residue:326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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  Blast E-value cutoff:
BDBM50387298
n/a
NameBDBM50387298
Synonyms:CHEMBL2048872
TypeSmall organic molecule
Emp. Form.C21H21N3O2S
Mol. Mass.379.475
SMILESN[C@@H]1CCCN(C1)c1c(C=C2SC(O)=NC2=O)cccc1-c1ccccc1 |r,w:9.9,c:14|
Structure
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