Reaction Details |
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Target | Maternal embryonic leucine zipper kinase |
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Ligand | BDBM50026612 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1679543 (CHEMBL4029820) |
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Ki | 5.6±n/a nM |
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Citation | Edupuganti, R; Taliaferro, JM; Wang, Q; Xie, X; Cho, EJ; Vidhu, F; Ren, P; Anslyn, EV; Bartholomeusz, C; Dalby, KN Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem25:2609-2616 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Maternal embryonic leucine zipper kinase |
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Name: | Maternal embryonic leucine zipper kinase |
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
Type: | Enzyme |
Mol. Mass.: | 74665.45 |
Organism: | Homo sapiens (Human) |
Description: | Q14680 |
Residue: | 651 |
Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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BDBM50026612 |
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n/a |
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Name | BDBM50026612 |
Synonyms: | BIBF-1120 | Nintedanib | US10981896, Compound Nintedanib | US11046672, Nintedanib | US11208381, Nintedanib | Vargatef |
Type | Small organic molecule |
Emp. Form. | C31H33N5O4 |
Mol. Mass. | 539.6248 |
SMILES | COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |
Structure |
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