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TargetThymidylate synthase
LigandBDBM50005335
Substrate/Competitorn/a
Meas. Tech.ChEBML_208947
Ki 5±n/a nM
Citation Reich, SHFuhry, MANguyen, DPino, MJWelsh, KMWebber, SJanson, CAJordan, SRMatthews, DASmith, WW Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. J Med Chem35:847-58 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | Thymidylate Synthase (TS) | Thymidylate synthase | thyA
Type:n/a
Mol. Mass.:30487.86
Organism:Escherichia coli
Description:n/a
Residue:264
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWIGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
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  Blast E-value cutoff:
BDBM50005335
n/a
NameBDBM50005335
Synonyms:2-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]quinolin-5-ylmethyl)-benzoylamino]-pentanedioic acid | CHEMBL169411
TypeSmall organic molecule
Emp. Form.C23H25N5O5
Mol. Mass.451.4751
SMILESNc1nc2cc3CCCN(Cc4ccc(cc4)C(=O)NC(CCC(O)=O)C(O)=O)c3cc2[nH]1
Structure
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