| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-sensitive inward rectifier potassium channel 1 |
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| Ligand | BDBM50249187 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1679734 (CHEMBL4030011) |
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| IC50 | 42±n/a nM |
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| Citation |  Dong, S; VanGelder, K; Shi, ZC; Yu, Y; Wu, Z; Ferguson, R; Guo, ZZ; Tang, H; Frie, J; Fu, Q; Gu, X; Priest, BT; Thomas-Fowlkes, B; Weinglass, A; Margulis, M; Liu, J; Pai, LY; Hampton, C; Haimbach, RE; Owens, K; Tong, V; Xu, S; Hu, M; Zingaro, GJ; Morissette, P; Ehrhart, J; Roy, S; Sullivan, K; Pasternak, A Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett27:2559-2566 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-sensitive inward rectifier potassium channel 1 |
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| Name: | ATP-sensitive inward rectifier potassium channel 1 |
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| Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44809.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_223460826 |
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| Residue: | 391 |
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| Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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| BDBM50249187 |
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| n/a |
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| Name | BDBM50249187 |
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| Synonyms: | CHEMBL4075415 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N4O5 |
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| Mol. Mass. | 466.5295 |
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| SMILES | C[C@@H]([C@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)c2ccc(=O)n(C)n2)CC1 |r| |
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| Structure | 
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