Reaction Details |
| Report a problem with these data |
Target | Muscarinic acetylcholine receptor M4 |
---|
Ligand | BDBM50249404 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1679899 (CHEMBL4030176) |
---|
EC50 | 1540±n/a nM |
---|
Citation | Melancon, BJ; Wood, MR; Noetzel, MJ; Nance, KD; Engelberg, EM; Han, C; Lamsal, A; Chang, S; Cho, HP; Byers, FW; Bubser, M; Jones, CK; Niswender, CM; Wood, MW; Engers, DW; Wu, D; Brandon, NJ; Duggan, ME; Conn, PJ; Bridges, TM; Lindsley, CW Optimization of M Bioorg Med Chem Lett27:2296-2301 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Muscarinic acetylcholine receptor M4 |
---|
Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
|
|
|
BDBM50249404 |
---|
n/a |
---|
Name | BDBM50249404 |
Synonyms: | CHEMBL4066953 |
Type | Small organic molecule |
Emp. Form. | C21H18FN5OS |
Mol. Mass. | 407.464 |
SMILES | Cc1nnc2sc(C(=O)NCc3ccc(cc3)-c3ccncc3F)c(N)c2c1C |
Structure |
|