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TargetCytochrome P450 2D6
LigandBDBM50249435
Substrate/Competitorn/a
Meas. Tech.ChEBML_1679903
IC50 1300±n/a nM
Citation Melancon, BJWood, MRNoetzel, MJNance, KDEngelberg, EMHan, CLamsal, AChang, SCho, HPByers, FWBubser, MJones, CKNiswender, CMWood, MWEngers, DWWu, DBrandon, NJDuggan, MEConn, PJBridges, TMLindsley, CW Optimization of M Bioorg Med Chem Lett27:2296-2301 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50249435
n/a
NameBDBM50249435
Synonyms:CHEMBL4070692
TypeSmall organic molecule
Emp. Form.C21H19N5OS
Mol. Mass.389.473
SMILESCc1nnc2sc(C(=O)NCc3ccc(cc3)-c3ccncc3)c(N)c2c1C
Structure
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